ChloroquineV1, France, Analysis, bibRecord, 000094

Simultaneous UHPLC-UV analysis of hydroxychloroquine, minocycline and doxycycline from serum samples for the therapeutic drug monitoring of Q fever and Whipple's disease

Identifieur interne : 000094 ( France/Analysis ); précédent : 000093; suivant : 000095

Simultaneous UHPLC-UV analysis of hydroxychloroquine, minocycline and doxycycline from serum samples for the therapeutic drug monitoring of Q fever and Whipple's disease

Auteurs : Nicholas Armstrong [France] ; Magali Richez [France] ; Didier Raoult [France] ; Eric Chabriere [France]

Source :

Journal of Chromatography B - Analytical Technologies in the Biomedical and Life Sciences [ 1570-0232 ] ; 2017-08.

RBID : Hal:hal-01730958

Abstract

A fast UHPLC-UV method was developed for the simultaneous analysis of Hydroxychloroquine, Minocycline and Doxycycline drugs from 100 mu L of human serum samples. Serum samples were extracted by liquid liquid extraction and injected into a phenyl hexyl reverse phase column. Compounds were separated using a mobile phase linear gradient and monitored by UV detection at 343 nm. Chloroquine and Oxytetracycline were used as internal standards. Lower and upper limits of quantifications, as well as the other levels of calibration, were validated with acceptable accuracy (< 15% deviation) and precision (< 15% coefficient of variation) according to the European Medicines Agency guidelines. This new method enables cost and time reduction and was considered suitable for the clinical laboratory. It is the first published assay for the therapeutic drug monitoring of patients diagnosed with Q fever or Whipple's disease.

Url:

https://hal.archives-ouvertes.fr/hal-01730958

DOI: 10.1016/j.jchromb.2017.06.011

Affiliations:

Links toward previous steps (curation, corpus...)

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Links to Exploration step

Hal:hal-01730958

Le document en format XML

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          <orgName type="acronym">AMU</orgName>
          <date type="start">2012-01-01</date>
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<country>France</country>
<placeName><settlement type="city">Marseille</settlement>
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<orgName type="university">Université d'Aix-Marseille</orgName>
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<author><name sortKey="Chabriere, Eric" sort="Chabriere, Eric" uniqKey="Chabriere E" first="Eric" last="Chabriere">Eric Chabriere</name>
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          <orgName>Aix Marseille Université</orgName>
          <orgName type="acronym">AMU</orgName>
          <date type="start">2012-01-01</date>
          <desc>            <address>              <addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.univ-amu.fr/</ref>
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          <orgName type="acronym">INSERM</orgName>
          <desc>            <address>              <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
</tutelle>
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          <date type="start">1996-01-01</date>
          <date type="end">2011-12-31</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
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            </address>
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</tutelle>
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          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
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</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Marseille</settlement>
<region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
</placeName>
<orgName type="university">Université d'Aix-Marseille</orgName>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.1016/j.jchromb.2017.06.011</idno>
<series><title level="j">Journal of Chromatography B - Analytical Technologies in the Biomedical and Life Sciences</title>
<idno type="ISSN">1570-0232</idno>
<imprint><date type="datePub">2017-08</date>
</imprint>
</series>
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<front><div type="abstract" xml:lang="en">              <p>A fast UHPLC-UV method was developed for the simultaneous analysis of Hydroxychloroquine, Minocycline and Doxycycline drugs from 100 mu L of human serum samples. Serum samples were extracted by liquid liquid extraction and injected into a phenyl hexyl reverse phase column. Compounds were separated using a mobile phase linear gradient and monitored by UV detection at 343 nm. Chloroquine and Oxytetracycline were used as internal standards. Lower and upper limits of quantifications, as well as the other levels of calibration, were validated with acceptable accuracy (< 15% deviation) and precision (< 15% coefficient of variation) according to the European Medicines Agency guidelines. This new method enables cost and time reduction and was considered suitable for the clinical laboratory. It is the first published assay for the therapeutic drug monitoring of patients diagnosed with Q fever or Whipple's disease.</p>
            </div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
</country>
<region><li>Provence-Alpes-Côte d'Azur</li>
</region>
<settlement><li>Marseille</li>
</settlement>
<orgName><li>Université d'Aix-Marseille</li>
</orgName>
</list>
<tree><country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Armstrong, Nicholas" sort="Armstrong, Nicholas" uniqKey="Armstrong N" first="Nicholas" last="Armstrong">Nicholas Armstrong</name>
</region>
<name sortKey="Chabriere, Eric" sort="Chabriere, Eric" uniqKey="Chabriere E" first="Eric" last="Chabriere">Eric Chabriere</name>
<name sortKey="Raoult, Didier" sort="Raoult, Didier" uniqKey="Raoult D" first="Didier" last="Raoult">Didier Raoult</name>
<name sortKey="Richez, Magali" sort="Richez, Magali" uniqKey="Richez M" first="Magali" last="Richez">Magali Richez</name>
</country>
</tree>
</affiliations>
</record>

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{{Explor lien
   |wiki=    Sante
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   |texte=   Simultaneous UHPLC-UV analysis of hydroxychloroquine, minocycline and doxycycline from serum samples for the therapeutic drug monitoring of Q fever and Whipple's disease
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Simultaneous UHPLC-UV analysis of hydroxychloroquine, minocycline and doxycycline from serum samples for the therapeutic drug monitoring of Q fever and Whipple's disease

Simultaneous UHPLC-UV analysis of hydroxychloroquine, minocycline and doxycycline from serum samples for the therapeutic drug monitoring of Q fever and Whipple's disease

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